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The importance of a Personalized Preparations

Commercial probiotics might not work because our microbiota is a delicate ecosystem where thousands of bacterial species coexist and balance each other. Taking random probiotics without knowing which bacteria are already present in our gut and which are the probiotic species already validated for your discomfort, can lead to dysbiosis, an imbalance in the bacterial population. If one is in good health, they can take probiotics to maintain it. However, if there’s a specific need related to gut microbiota health, it’s better to undergo a microbiome test for a better understanding of what’s happening and then act accordingly. This could involve personalized preparation and a balanced diet.

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Please note that this service has been created for customers who have taken the microbiome test and are followed by one of our doctors or nutritionists. If you have not done our gut health test yet, write to us and we can guide you.

  1. Choose the probiotic* raw material from the following list
  2. Choose the prebiotic* raw material from the following list
  3. Pay and write the address for the delivery and wait for the results!

* Click on the individual raw materials, to access all the research citations related to the individual item.

Customized Galenic Preparations by MATTHIOS D. & VASSILOPOULOU S.O.E. Pharmacy, Nea Erithrea, Athens, Greece.

Our personalized galenic preparations are exclusively tailored for you by the renowned pharmacy MATTHIOS D. & VASSILOPOULOU S.O.E., located in Nea Erithrea, Athens, Greece. The BioArte closely collaborates with this pharmacy, which, based on the specifications provided by us, crafts personalized preparations to meet your unique needs. Please note that preparations will be ordered through our platform and shipped directly from Greece, ensuring the highest quality and customization of the product. Shipping is available throughout the EU (except UK).

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Probiotics

The use of Bifidobacterium breve probiotics has shown an anti-inflammatory effect, positive results in adjusting the microbial composition1 in patients with Celiac disease, resulting in decreased constipation-related symptoms2. B. breve is also used as a prevention for gastrointestinal symptom3 and rebalance the intestinal microbiota in infants and children4.

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The use of B. infantis  promotes immunoregulatory responses1, relieves many of the symptoms of irritable bowel syndrome3 and significantly improves the cure rates of H. pylory infection5. Supplementation of B. infantis within the first month of life results in stable colonization persisting for at least a year2 and together with L. acidophilus can be an effective treatment for acute watery diarrhea in infants4.

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The use of Bifidobacterium lactis probiotics for the treatment of constipation has been investigated and showed substantial improvement in the frequency of bowel movements, consistency of stool and reduction of abdominal discomfort1. Studies have shown that B. lactis probiotics have shown improvement in the cases of leaky gut, resulting in the decrease of the whole gut transit time and increased stool frequency and stool consistency2. Supplementation of B. lactis by caesarean-delivered infants can increase anti-rotavirus and anti-poliovirus immunoglobulins3.

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The use of Bifidobacterium longum probiotics in the treatment of chronic constipation, has shown favourable effects when combined with fructo-oligosaccharides (FOS) in weight loss interventions1, enhancing stool frequency, and reducing abdominal pain in patients with Irritable Bowel Syndrome (IBS) 2. Studies have shown that B. longum assists in repopulating the intestinal microbiota3, especially after a course of medication4 that eradicates the bacterial overgrowth. Combining B. longum with FOS has shown positive biochemical and neuropsychological results5  have also been seen with patients suffering from Minimal Hepatic Encephalopathy (MHE), and increases the Bifidobacteria population6 in permanent vegetative status (PVS) patients.

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The use of Lacticaseibacillus paracasei has been shown to relieve constipation and improve the potentially depressive symptoms in patients with depression1, help prevent cardiometabolic diseases2, alleviate airway allergic inflammation in children3, ameliorate gastrointestinal function in infants and toddlers4, help maintain physical condition in healthy adults6 and moderate symptoms of halitosis10. The use of L. paracasei  had favourable effects in managing constipation in Parkinson's disease patients5 and provided protective, accelerated recovery and anti-fatigue benefits after muscle damage9. It can also ameliorate hypercholesterolemia and prevent or delay the development of atherosclerosis7. L. paracasei contained in a lotion is safe and effective for treating mild to moderate acne vulgaris8. Overall administration of L. paracasei showed a positive effect on the vaginal microbial ecosystem11. Regular intake of L. paracasei significantly reduces symptoms of moderate to severe dandruff12.

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The use of Lacticaseibacillus rhamnosus has shown a beneficial effect on diarrhea1 including rotaviral diarrhea2, oral health6, atopic dermatitis and cow’s milk allergy3. It can be used to prevent necrotizing enterocolitis4 and prevent respiratory infections5 in children, as well as prevent infections7 in malnourished children. In vitro studies has shown protective role of L. rhamnosus against Group B Streptococcus8 colonization in vaginal tract. Individuals with overweight undergoing weight loss benefit from L. rhamnosus supplementation, which induces favorable metabolic and psychological outcomes9.

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The use of Lactipantibacillus plantarum has shown protective effects against age-related memory decline in older individuals1, as well as exhibiting an immunostimulatory effect10 that could be used to improve the response to influenza vaccination in the elderly. It can also help to prevent and treat early childhood caries2 and combat pathogenic infections such as E. coli in infants11. Intake of L. plantarum improves irritable bowel syndrome symptom severity3, enhances intestinal discomfort, overall intestinal health, and defecation consistency5 and also provides chronic constipation relief effect7. It can also improve cognitive functions by ameliorating aspects of mood and sleep6 and relieve stress resulting from temporary load4. Due to its antioxidative effect on blood lipids L. plantarum can be used for management of cardiovascular diseases risk8, with potentially anti-obesogenic effects9.

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The use of Lactobacillus acidophilus probiotics has been shown to improve small bowel pathobiology1, soothe lactose intolerance symptoms2, reduce inflammation factors3, and lower abdominal pain caused by irritable bowel syndrome4. Lactobacillus acidophilus supplementation combined with atomoxetine had a beneficial impact on ADHD symptomology and a favourable influence on cognitive performance in adults and children5.

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The use of Lactobacillus crispatus probiotics are effective against bacterial vaginosis and vulvovaginal candidiasis being suitable for both vaginal and oral administration1. L. crispatus supplementation contributes to lowering the recurrence of bacterial vaginosis2 and significantly reducing H. pylori load3. Daily intake of L. crispatus KT-11 can prevent periodontal disease through the improvement of oral conditions4. L. crispatus dominated cervicovaginal microbiota are associated with a lower prevalence of HIV and STIs5.

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The of use of Lactobacillus gasseri as a long-term supplement has shown improvement in the mental state, sleep quality, and gut microbiota of healthy adults under stressful conditions1, reduced visceral fat mass in obese adults2, provide a significant relief in mild symptoms associated with menopause3 and effectively reduce symptoms in subjects with a high predisposition to allergies4. L. gasseri shows a beneficial effect on functional dyspepsia without H. pylori involvement5, irritable bowel syndrome6, and metabolic disorders7. L. gasseri together with L. crispatus can restore the vaginal health of patients recovering from bacterial vaginosis8.

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The use of Limosilactobacillus reuteri probiotics is known for its versatile applications as it serves various health purposes across different conditions. It shows efficacy in alleviating symptoms of respiratory infections in children1 and acts as an adjunct treatment for chronic periodontitis2. Moreover, it enhances the long-term effectiveness of mRNA-based COVID-19 vaccines3 and aids in the treatment of acute uncomplicated diverticulitis4. In addition, it mitigates colic symptoms in infants5 and inhibits H. pylori growth, thereby reducing antibiotic-associated side effects6. This versatile probiotic contributes to managing pregnancy gingivitis7 and decreases episodes and duration of diarrhoea and respiratory tract infections in healthy children8. Furthermore, it reduces salivary S. mutans counts9, alleviates abdominal pain intensity10, and improves early feeding tolerance in preterm infants, promoting growth and shortening hospital stays11. It also modifies inflammatory parameters, alters the gastrointestinal microbiome12, and accelerates nutritional recovery in children with anorexia nervosa13. Lastly, as an adjunct to rehydration therapy, it benefits children with acute gastroenteritis14. Notably, L. reuteri is a prolific producer of vitamin B1215 and reuterin16.

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The use of Saccharomyces boulardii, a beneficial yeast probiotic, has been shown as a positive treatment of acute gastroenteritis1, enhancing the immune response2, and the prevention of antibiotic-associated diarrhoea in the pediatric population3. S. boullardii has been shown to prevent antibiotic-associated diarrhoea (AAD) known as traveler’s diarrhoea4, as well as the use of this yeast probiotic for the prevention of enteral nutrition-related diarrhoea5. This yeast is best known in the treatment against H. pylori infection6, as well as the prevention of antibiotic-associated diarrhoea7 due to the infection in adults and children8. In infants, S. boullardii has shown promise in C. difficile-associated enteropathies9, the prevention of C. difficile disease recurrences10 when combined with other treatment methods11. Intake of the probiotic has shown to assist in the maintenance of Crohn’s disease11, ulcerative colitis12, post-treatment for antibiotic-associated diarrhoea13, as well as reduce dysbiosis caused by specific antibiotics15.

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Prebiotics

The use of Fructo-oligosaccharides known as FOS, as a prebiotic, has shown positive effects on beneficial bacteria. FOS are non-caloric and atypical sugars unmetabolized by the human body, yet fermentable by the colonic microbiota, delivering favorable impacts on mineral and trace element absorption. Enhanced mineral absorption2, particularly calcium, magnesium, and iron, subsequent to FOS intake. Postmenopausal women experienced heightened absorption of minerals and trace elements. Apart from mineral absorption, FOS has also shown positive effects on carbohydrate and lipid metabolism, hormone balance, and nitrogen homeostasis. The prebiotic showcases the potential applications in reducing the risk of various diseases7, including constipation, infectious diarrhoea, cancer, osteoporosis, atherosclerotic cardiovascular disease, obesity, and non-insulin dependent diabetes3. FOS's positive impact1 on beneficial bacteria like Lactobacillus and Bifidobacterium5, resulting in a reduction in potentially harmful bacteria4, alongside butyrate-producing6 microbes such as Faecalibacterium, Ruminococcus, and Oscillospira, showcase the potential of FOS in promoting the growth of beneficial gut bacteria and enhancing bacterial diversity, conferring valuable advantages to the host's overall health.

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The use of Galacto-oligosaccharides known as GOS, as a prebiotic, has demonstrated a significant impact on the body's intestinal flora. GOS are oligosaccharides formed via β-galactosidase transgalactosylation1, that are indigestible food components which travel through the upper gastrointestinal tract without breaking down and reach the colon intact, where they ferment, producing short-chain fatty acids (SCFAs) that contribute to the modulation of the intestinal microbiota. GOS has shown positive effects on self-reported high trait anxiety, attentional bias, and bacterial abundance. This suggests that including a GOS prebiotic in the diet could potentially enhance indicators associated with pre-clinical anxiety2.

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The use of Inulin as a prebiotic has shown to play a role in various functions. Inulin is a mixture of polymers and oligomers, which is composed of fructose units connected by β (2-1) glycosidic bonds. Because of this β configuration, inulin is resistant to the hydrolysis of human digestive enzymes and cannot be digested, so it can completely reach the large intestine and be selectively fermented by colonic bacteria. The prebiotic contributes to promoting the growth of beneficial gut bacteria, boosting immune function by improving digestive health and bowel function7 in individual with chronic constipation8, support in mineral absorption, modulate blood sugar level1, plays a role in weight management by increasing satiety. Inulin supplementation has shown to benefit individuals with diabetes2, and these effects might be further enhanced with the addition of a butyrate supplement. The prebiotic has also shown impact of increasing colonic propionate delivery on insulin sensitivity, the plasma metabolome, gut bacterial populations, and markers of systemic inflammation3, as well as increasing the abundance of Prevotella, contributing in glucose metabolism improvement4, increase the proportion of Bifidobacteria in the intestines and reduce the amount of Clostridium and Bacteroides5 species. Inulin-propionate easter has shown to decrease the surplus lipogenic substrate to the liver, possibly attenuating liver fat accumulation in individuals with non-alcoholic fatty liver disease6. Inulin has also shown to improve glycemic control, insulin resistance, and blood pressure9.

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