Inulin 60 capsules (500mg/capsule)

30.00

The use of Inulin as a prebiotic has shown to play a role in various functions. Inulin is a mixture of polymers and oligomers, which is composed of fructose units connected by β (2-1) glycosidic bonds. Because of this β configuration, inulin is resistant to the hydrolysis of human digestive enzymes and cannot be digested, so it can completely reach the large intestine and be selectively fermented by colonic bacteria. The prebiotic contributes to promoting the growth of beneficial gut bacteria, boosting immune function by improving digestive health and bowel function7 in individual with chronic constipation8, support in mineral absorption, modulate blood sugar level1, plays a role in weight management by increasing satiety. Inulin supplementation has shown to benefit individuals with diabetes2, and these effects might be further enhanced with the addition of a butyrate supplement. The prebiotic has also shown impact of increasing colonic propionate delivery on insulin sensitivity, the plasma metabolome, gut bacterial populations, and markers of systemic inflammation3, as well as increasing the abundance of Prevotella, contributing in glucose metabolism improvement4, increase the proportion of Bifidobacteria in the intestines and reduce the amount of Clostridium and Bacteroides5 species. Inulin-propionate easter has shown to decrease the surplus lipogenic substrate to the liver, possibly attenuating liver fat accumulation in individuals with non-alcoholic fatty liver disease6. Inulin has also shown to improve glycemic control, insulin resistance, and blood pressure9.

Description

Dosage: 500mg per capsule

Capsules per order: 60 capsules

Instructions: 2 capsules daily (morning & evening)

Citations:

  1. Rao M, Gao C, Xu L, et al.. Effect of Inulin-Type carbohydrates on insulin resistance in patients with type 2 diabetes and obesity: a systematic review and meta-analysis. J Diabetes Res 2019;2019:1–13. 10.1155/2019/5101423. https://pubmed.ncbi.nlm.nih.gov/31534973/
  2. Roshanravan N, Mahdavi R, Alizadeh E, et al.. Effect of butyrate and inulin supplementation on glycemic status, lipid profile and glucagon-like peptide 1 level in patients with type 2 diabetes: a randomized double-blind, placebo-controlled trial. Horm Metab Res 2017;49:886–91. 10.1055/s-0043-119089. https://pubmed.ncbi.nlm.nih.gov/28962046/
  3. Chambers ES, Byrne CS, Morrison DJ, et al.. Dietary supplementation with inulin-propionate ester or inulin improves insulin sensitivity in adults with overweight and obesity with distinct effects on the gut microbiota, plasma metabolome and systemic inflammatory responses: a randomised cross-over trial. Gut 2019;68:1430–8. https://pubmed.ncbi.nlm.nih.gov/30971437/
  4. Kovatcheva-Datchary P, Nilsson A, Akrami R, et al.. Dietary fiber-induced improvement in glucose metabolism is associated with increased abundance of Prevotella. Cell Metab 2015;22:971–82. 10.1016/j.cmet.2015.10.001. https://pubmed.ncbi.nlm.nih.gov/26552345/
  5. Vandeputte D, Falony G, Vieira-Silva S, Wang J, Sailer M, Theis S, Verbeke K, Raes J. Prebiotic inulin-type fructans induce specific changes in the human gut microbiota. Gut. 2017;66:1968–1974. doi: 10.1136/gutjnl-2016-313271. https://pubmed.ncbi.nlm.nih.gov/28213610/
  6. Chambers ES, Byrne CS, Rugyendo A, et al.. The effects of dietary supplementation with inulin and inulin-propionate ester on hepatic steatosis in adults with non-alcoholic fatty liver disease. Diabetes Obes Metab 2019;21:372–6. https://pubmed.ncbi.nlm.nih.gov/30098126/
  7. Collado Yurrita L, San Mauro Martín I, Ciudad-Cabañas MJ, et al.. Effectiveness of inulin intake on indicators of chronic constipation; a meta-analysis of controlled randomized clinical trials. Nutr Hosp 2014;30:244–52. 10.3305/nh.2014.30.2.7565. https://pubmed.ncbi.nlm.nih.gov/25208775/
  8. Micka A, Siepelmeyer A, Holz A, et al.. Effect of consumption of chicory inulin on bowel function in healthy subjects with constipation: a randomized, double-blind, placebo-controlled trial. Int J Food Sci Nutr 2017;68:82–9. 10.1080/09637486.2016.1212819. https://pubmed.ncbi.nlm.nih.gov/27492975/
  9. Cai X, Yu H, Liu L, et al.. Milk powder Co-Supplemented with inulin and resistant dextrin improves glycemic control and insulin resistance in elderly type 2 diabetes mellitus: a 12-week randomized, double-blind, placebo-controlled trial. Mol Nutr Food Res 2018;62:e1800865:1800865. 10.1002/mnfr.201800865. https://pubmed.ncbi.nlm.nih.gov/30346655/