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The BioArte

Who we are

Our expertise lies in the fields of Next Generation Sequencing (NGS) and medical diagnostics. As pioneers in our field, we are among the top ten emerging next-generation sequencing companies in Europe. We have embraced the revolutionary nanopore sequencing technology in order to advance our therapeutic approaches. Our focus lies in the power of microbiota to develop innovative solutions.

Our pipeline enables us to delve further into species-level taxonomy classification with a swift, cost-effective, and dependable process. It is fast, as we can generate a microbiome taxonomy plot within minutes of receiving the fastq file. It is cost-effective because we achieve species-level classification without employing a shotgun approach. Furthermore, it is reliable, boasting an accuracy rate exceeding 99%.

With access to ONT (Oxford Nanopore Technologies) technology as a foundation, our company develops ground-breaking solutions encompassing laboratory protocols, bioinformatics tools, scripts, and algorithms. These innovations empower the utilization of nanopore sequencing to develop revolutionary solutions at the intersection of microbiota, innovative therapeutics, and human genetics. Our accomplished team of specialists in bioinformatics and molecular genetics works to create cutting-edge solutions that address modern challenges in these areas.

Our Molecular Diagnostics Laboratory utilizes the Real-Time PCR technique for pathogen detection and quantification in both research and diagnostic settings. It is worth noting that The BioArte Ltd. holds an ISO 9001:2015 certification, further enhancing our credibility.

The BioArte Ltd. Christian Duchow co founder

Christian Duchow

Born in Hamburg, he is an entrepreneur with extensive experience in the pharmaceutical field and the founder of several Healthcare companies. He is considered a top-level expert in the pharmaceutical industry worldwide. Having established an extensive business network, he is keen on identifying business opportunities globally, sourcing the necessary associates, and implementing the strategic opportunities arising. His leadership is focused on the value of people and his ability to create teams and develop key people within them to achieve the required goals have led to his success throughout the years.
After holding management positions in several German-Swiss and Belgium pharmaceutical companies, he founded the PharOS Group in 2002, with offices in Greece, Cyprus, and Malta, and in 2003 he co-founded the PharmSol Group in the United Arab Emirates with offices in Germany, Malta, India, and China. Since 2016 he has been director of The Materia Company Ltd. and in 2019 he founded and directs the company The Bio Arte Limited in Malta.

The BioArte Dr. Manuele Biazzo founder

Dr. Manuele Biazzo

Born in Breno and raised in the Italian region of Basilicata, after a doctorate in molecular biology at the University of Bologna, Manuele Biazzo has gained a long professional experience ranging from the pharmaceutical sector to microbiology, as well as the development of personal care products.
For seven years he served as Director of Research and Development for a company based in Malta and was active in the health sector. Today he is a partner and director of The Bio Arte.

What we do

Next-Generation Sequencing

Methods for Results that Matter

The amount and richness of information obtainable from sequencing data have undergone a remarkable expansion, evolving from Sanger sequencing to advanced Next Generation Sequencing (NGS) techniques. As a result, the cost of sequencing has plummeted significantly.

In recent years, numerous innovative sequencing technologies have emerged, including those capable of sequencing individual DNA molecules. Among these advancements, nanopore sequencing, utilizing minuscule apertures on cell membranes, presents distinct advantages over existing methods reliant on optical or pH changes for DNA sequence detection.

Why Nanopore?

The utilization of nanopore technology brings forth numerous advantages:

  1. Flexibility and Versatility: Nanopore technology is highly adaptable and can be applied across various sequencing applications, accommodating diverse research needs.
  2. Single-Molecule Sequencing: With nanopore technology, it becomes possible to sequence individual DNA molecules, providing detailed insights into genetic information at the molecular level.
  3. Both Short and Long Read Lengths: Nanopore sequencing enables the generation of reads spanning different lengths, allowing for comprehensive coverage and analysis of genetic sequences.
  4. Real-Time Data Generation and Analysis: One of the key strengths of nanopore technology is its ability to produce sequencing data in real-time. This enables researchers to gain immediate insights, make data-driven decisions, and conduct rapid analysis.
  5. Cost-Effectiveness: Nanopore sequencing has witnessed a reduction in the overall cost of sequencing, making it a cost-effective solution compared to traditional sequencing methods. This affordability facilitates broader accessibility and opens up opportunities for researchers with varying budgets.

By harnessing the power of nanopore technology, researchers can benefit from its versatility, single molecule sequencing capabilities, flexibility in read lengths, real-time data analysis, and cost-effectiveness, leading to advancements in genomics research and beyond.

How Nanopore works

Nanopore-based sequencing technology operates by detecting distinctive electrical signals emitted by various molecules as they traverse a nanopore using a semiconductor-based electronic detection system. This approach offers a cost-effective and high-throughput solution for sequencing. The core of this technology revolves around a biological nanopore—a protein pore nestled within a membrane—while the intelligence resides in the electronics of a semiconductor integrated circuit, coupled with proprietary chemistries. Within the chip, the embedded electronic sensor technology enables automated membrane assembly, nanopore insertion, and individual sensor control.

To achieve high throughput and accuracy, different sequencing chemistries can be combined with the nanopore and electronic sensor technology, expediting the time required to obtain sequencing data.

What we are able to provide with our species level taxonomy classification?

Reaching the species levels has opened many opportunities and has expanded our possibilities. These include;

  1. Personalised Probiotic recommendation
  2. Biomarkers discovery
  3. New Probiotic development
  4. New delivery systems for existing oral Probiotics

How we do it

The Structure of The BioArte Ltd.

Research Lab

Medical Diagnostic Lab



Research Lab

Project #1 Diagnostic for Skin and Gut Phenotypes Predictive of Healthy Ageing

Project Objective: The overall objective of this project is the discovery and typing of both known and novel microbiome types from both skin and gut that in turn can be correlated with health, longevity and healthy ageing

Lead Partner: TopMD Precision Medicine Ltd, a UK-registered company, operating in the drug development and precision medicine segment.

Project Tasks:

  1. Clinical samples were sequenced at the microbiome level using an optimization mapping methodology; Analysis of microbiome complement for patients of the study cohorts, people aged 50 – 80 with and without inflammatory bowel disease (IBD) and/or neurodegenerative disease.
  2. Analysis of host transcriptome complement for patients of the study cohorts, people aged 50 – 80 with and without inflammatory bowel disease (IBD) and/or neurodegenerative disease, Optimisation of transcriptome mapping technology and gene expression mapping of samples by NGS tools;
  3. Analysis of NGS data for identification of biomarkers predictive of healthy ageing phenotypes
  4. Biomarkers identified for healthy ageing phenotypes related to IBD and neurodegenerative disease.

Project #2 Nasal Biomarkers Identification and characterisation to reduce severity and transmissibility of covid19, in vaccinated and not vaccinated population

Project Objective: The BioArte intends to design new and improved services to accurately offer a rapid sequence typing technique to determine Sars CoV-2 variants accurately, predict COVID-19 severity, and correlate this with the patient microbiome typing. The data obtained can be piloted as a data package that can, in turn, be used to design products or medicines that will be aimed at treating COVID-19 positive patients. BioArte will develop novel tools and methods for the analysis and manipulation of microbiomes

Project Tasks:

  1. Characterization and selection of patient samples, Bacterial genomic DNA and SARS-CoV-2 RNA extraction from nasopharyngeal swab samples
  2. Selected DNA samples sequenced at the microbiome and selected RNA samples shall be sequenced at SARS-CoV-2 whole genome level
  3. Determination of the full microbiome in COVID-19 positive patients (symptomatic or asymptomatic), uninfected patients and vaccinated ones. The human nasopharynx microbiome in COVID-19 positive patients and it is differentially expressed as opposed to the microbiome of healthy patients.
  4. Analysis of required omics-based bioinformatics.

Project #3 Skin MicroBiome Restorative Therapy

Project approved by FUSION R&I Technology Development Programme LITE MCST

Project Objective: The main aim of the project is to study a novel topical application of live lactobacilli that will re-modulate cutaneous microbial interactions responses in subjects with skin problems such as acne and that will remain alive once delivered on the skin surface. This study will aim to investigate a topical formulation with live probiotic bacteria for cutaneous acceptability, safety, and efficacy under acne diseased skin pathology. The process that will be implemented will be focused in preparing the necessary dossier for registering our product (currently under cosmetic) as a pharmaceutical product under pharma law.

Project Tasks:

  1. For Pharma Product, to test efficacy and potency of probiotic formulation
  2. Human skin models will be developed to induce in vitro acneic skin models, measurement of metabolic status and lipid production by fluorescent microscope after probiotic application
  3. Genetic tools such as siRNA mediated gene silencing will be used to produce innovative skin acne models
  4. Potency test: In vitro penetration studies; Genomic characterization of the probiotic
  5. GMP production and test its efficacy on the above and sustain data with skin microbiome studies before and after treatment.

Project #4 Gut Microbiome personalise sports nutrition (GUMPS)

Project funding pending Malta Enterprise

Project Objective: Research has shown that there is a correlation between intestinal microbiota and exercise, suggesting that the microbiome plays a significant role in athletic performance. The gut microbiome is influenced by various factors, including diet, exercise, and genetics. However, most studies have focused on the gut microbiome as a single variable and have not investigated the interaction between the main elements of athletic performance: diet, exercise, genetic and microbiome.

This project aims to fill this gap in knowledge by integrating the effects of each nutritional factor with the type of sport, the individual’s training status, the athlete’s goals, the time of the competitive season, and the athlete’s food preferences. The project will also consider the influence of genetic polymorphisms on the gut microbiome and athletic performance. The objectives of the project will be achieved by analyzing the gut microbiome and host genetics before and after the implementation of a specific diet and exercise program. The project aims also to create a system that allows for the prediction of a specific diet’s effect on the athlete’s gut microbiome.

Project Tasks:

  1. To collect and analyze observational data as to understand the impact of gut microbiome and host genetics on sports performance and the effects of dietary changes. Personalized dietary and fitness implementation recommendations based on the collected data will be provided, along with algorithm tools for microbiome analysis and correlation with health, sports performance, and nutritional changes.
  2. Ex-vivo microbiota anaerobic gut models to be tested and developed. To evaluate changes in ex-vivo microbiota with different diets and pharmaceutical products and to provide personalized recommendations for assessing changes in ex-vivo microbiota correlated to fitness.
  3. Aims to collect and analyze data from athletes to understand the correlation between microbiome, genetics, and sports performance. The study will compare the gut microbiome of athletes and non-athletes and assess the impact of different diets and exercise regimes on microbiome and genetic information. The ultimate goal is to develop algorithms to analyze data and draw correlations between microbiome, genetics, diet, and athletic performance.

Project #5 Raising youth awareness on microbiota towards the creation of VET pathways

Project Acronym Biomed + | Project Date 01/09/2022 – 01/03/2024

European Union Programmes Agency 

The strategic objective of the cooperation between The Bio Arte (TBA), Siena Bio Active Srl (SBA), and the University of Siena (UNISI) is to support new career paths for youths in the biomedical industry, particularly focusing on microbiota transplant (FMT) and microbiota treatment. To do so the integration of specialised training to complement the competences acquired during University, could enable youths to increase their employability prospects.

The project will focus on the Microbiota segment of the Biotech, sector, whose growth requires specific competences. On the other hand, increasing the awareness of youths exiting Secondary or Tertiary Education, VET and Universities, about the main characteristics of the microbiota segment and acquire basic competences on the subject, might represent a good opportunity.

Through its activities, BIOMED+ will contribute to innovating VET and finally making VET more attractive for youths. BIOMED+ increases youth employability, focusing on STEM competences contributes to reduce the Skills mismatch between the competences required by the industry and those actually available. In particular, the partners want to establish a stronger partnership in order to – acquire further information and data on the microbiota sector – design solutions to strengthen the set of skills and competences required by the industry – facilitate the youths’ uptake of a career in the industry – explore further means of cooperation

Project Objective:

  • Assess and compare the different legislation on FMT
  • Conduct a literature Review on FMT
  • Understand the level of knowledge of the industry stakeholders on FMT and Microbiota
  • Develop training content
  • Investigate how Erasmus + can support further development to meet the requirements identified and establish a roadmap for the further development of the action

Project Tasks:

  1. A comparative assessment of the legislation regulating FMT in different countries
  2. The review of the state of the art of research
  3. The design and conduction of surveys and interviews with key stakeholders
  4. The design of training units
  5. The testing of the training with 15 youths
  6. A study on how Erasmus+ can support further development of the actions.

The target of the project consists of youths aged between 18 and 25.

Medical Diagnostic Lab

The BioArte ISO 9001:2015 is an expert medical pathology testing, research, and development laboratory working with global medical, pharmaceutical, food, biotechnology, and clinical research organizations.

The laboratory provides a wide range of services in both diagnostic and microbiome research fields for both professionals and individuals.

The BioArte laboratory provides a range of services that includes:

  • Next-Generation Sequencing (NGS)
  • Polymerase Chain Reaction (PCR)
  • Immunoassay tests for Virology, Immunology & Biochemistry
The BioArte Nutrigenomics test

Nutrigenomics test

The BioArte genetic PRS tests

Polygenic Risk Scores (PRS)

The BioArte IgG Food intolerance test ivd 800x400 bkgrnd immunology

Food intolerance test

STD screen

HLA test for Celiac disease

Microbiota Gut test



First of its kind treatment for skin dysbiosis

Creating balance on two fronts: skin & gut

SkinDuo™ is a unique one-of-a-kind product developed by The BioArte, that is composed of 2 separate products that simultaneously target gastrointestinal health and skin homeostasis. When addressing imbalanced skin, it is also important to not only provide treatment to the skin but also assist in rebalancing the gut microbiota.

SkinDuo™ is a product that does just that. The formulation has been carefully selected and is composed of a topical mono-dose serum and a food supplement.

Find Out More
  • SkinDuo Probiotic Oral Capsules | Treatment for Skin Dysbiosis *Only in Malta*

  • Sale!

    SkinDuo Probiotic Topical Serum | Treatment for Skin Dysbiosis

    Original price was: €250.00.Current price is: €170.00.

Institute of Microbiome and Applied Sciences

The Institute of Microbiome and Applied Sciences has been granted the licence from the Higher Education Institution to provide the needed knowledge and resources to those working or studying in the field of microbial diagnostics and industrial microbial production.

The Institute offers a combination of Awards and Qualifications. It aims to upskill the competencies of potential learners through a combination of underpinning theoretical principles and practical applications, essentially building a bridge between theory and practical application.

Institute of Microbiome and Applied Sciences offers a combination of courses and hands-on experience through internships, focusing on scientific research in the fields of clinical and industrial microbiology.

The growing interest in the microbiota field is still a bridge to be formed between the research, and the practical clinical and industrial approaches. The Institute is the first in Malta to help professionals combine their current knowledge with today’s new practical approaches focused on microorganisms and their interactions with our health.

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Our Collaborations

We collaborate with prestigious scientific private and academic research institutions.