Nutrigenomics test

550.00650.00

Every kit contains the following:

  • x1 swab
  • A leaflet with instructions on how to collect the sample

A predictive DNA test that serves as a compass allowing you to identify areas of strength and weakness that guide you in choosing conscious behavior for a healthy life. The test identifies the presence of genetic variants that may be associated with a predisposition to develop a certain pathology.

This test provides information on the following:

  • Metabolic: regulation of hunger and food metabolism
  • Intolerances & Allergies: predisposition to allergies and intolerances
  • Micronutrients: deficiency of vitamins and mineral salts
  • Inflammatory: response to inflammatory stimuli

Additional test:

  • Pharmacogenomics: drug metabolism
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Description

About this test

Regulation of hunger and macronutrient metabolism

The test can help you understand some physiological phenomena characteristic of your body linked to the catabolism of foods (proteins, fats, and carbohydrates). The Metabolic module provides you with useful information on the balance between glucose and insulin (glycation and diabetes), the metabolism and transport of cholesterol and triglycerides, the deposition of fat mass, and the catabolism of amino acids. There is also a specific set of genes that are involved in the hormonal regulation of metabolism: adiponectin, leptin, ghrelin, NPY, catecholamines, thyroid hormones (alterations on the TSH receptor), melanocortin and melatonin. The Metabolic module will also allow you to evaluate the effectiveness and dangers of ketogenic diets on a purely scientific basis.

Genetic areas analyzed

  • Carbohydrate metabolism (SLC30A8, G6PC2, GCK, SI, G6PD)
  • Fatty acidmetabolism (ADRB2,APOC1, FADS1, HNF4A, LIPC,GCKR, LPL,ALG14,PKD2L1, GRCh38.p12, FADS1, TMEM25)
  • Amino acid metabolism (PPMK1, HAL, QDPR)
  • Metabolism-associated with endocrine system (NPY MC4R, FAIM2, RLEP, GHSR, ARL15, ADIPOQ, MTNR1B,SH2B1, TCF7L2,PPARG, FTO,PDE8B, TSHR,DIO1)

Statistical algorithms (PRS – Polygenic Risk Score)

  • Risk of being overweight/obesity
  • Risk of hyperglycaemia, insulin resistance, and type II diabetes
  • Alterations in the metabolism of cholesterol and triglycerides (dyslipidaemia)
Related markers

Blood sugar, glycated hemoglobin, sucrose, cholesterol, HDL, LDL, triglycerides, palmitic acid, palmitoleic acid, stearic acid, arachidonic acid, histidine, phenylalanine, NPY, leptin, ghrelin, adiponectin, insulin, melatonin, melanocortin, TSH, FT3, FT4.

Predisposition to allergies and intolerances

The test allows you to know your natural predisposition towards food allergies and intolerances including nickel, lactose, milk and egg proteins, salt, fructose, acetaldehyde, histamine, peanuts, iron, ethanol, caffeine, and sulfites (one of the most used food preservatives ). Inside the module there is HLA typing (DQ2-DQ8) for the evaluation of the predisposition to develop celiac disease: an unfavorable HLA combination determines an increased risk for the disease, while the absence of unfavorable variants makes it completely unlikely for symptoms to manifest. The test also evaluates some polymorphisms linked to gluten sensitivity, an intolerance that is difficult to diagnose and should not be confused with celiac disease. The Intolerances & Allergies module will be useful for identifying those foods – or substances – that have toxic activity towards your body.

Genetic areas analyzed

  • GRK4, ADD1, FLG, ALDOB, ALDOB, LTC, STAT6, KLF17, DLX2, SNRPB2, MIR4535, ALDH2, CYP1A2, HFE, GCLC, CBS, DAO, G6PD, HLA-DQ 2, HLA-DQ 8, ASH1L, GRB10, FOS.

Statistical algorithms (PRS – Polygenic Risk Score)

  • Gluten sensitivity
  • Salt sensitivity
  • Sensitivity to nickel
  • Sensitivity to fructose
  • Lactose sensitivity
  • Sensitivity to milk proteins
  • Sensitivity to peanuts
  • Sensitivity to eggs
  • Sensitivity to ethanol (wine, beer, and spirits)
  • Sensitivity to caffeine (coffee, tea, cocoa, and guarana)
  • Sensitivity to iron (hemochromatosis)
  • Sensitivity to Mercury (toxicity)
  • Sensitivity to Sulfur (cruciferous vegetables, eggs, and garlic)
  • Sensitivity to sulfites and folate
  • Sensitivity to histamine
  • Predisposition to favism
  • Predisposition to celiac disease
  • Gluten sensitivity (intolerance)

Deficiency of vitamins and mineral salts

The test evaluates the genetic predisposition towards the deficiency of specific micronutrients essential for your health. Micronutrients, i.e. vitamins (A, B, C, D, E, and K), minerals (calcium, phosphorus, and magnesium), and trace elements (iron, zinc, and selenium) are important for the correct functioning of the body. Although the body needs them in small quantities, they play a vital role in the production of enzymes, hormones, and other substances that help regulate the growth, activity, development, and proper functioning of the immune and reproductive systems. Genetically based deficiencies of micronutrients are to be considered “constitutive”, therefore requiring nutritional integration courses throughout life. The Micronutrients module will provide you with a simple and clear overview of all the micronutrients that you will need to include in your diet (both as foods and as supplements) to balance the imbalances that may have generated situations of discomfort or illness.

Genetic areas analyzed

  • BCO1, NBPF3, MTHFR, FUT2, TCN1, SLC23A1, VDR, CYP24A1, GC, CYP4F2, ABCA1, IHPK3, ALPL,
    VKORC1,SLC30A8,PPCDC,DMGDH,MUC1,ATP2B1, TMPRSS6, NQO1.

Statistical algorithms (PRS – Polygenic Risk Score)

  • Vitamin D (deficiency | effectiveness)
  • Vitamin A
  • Lutein, Zeaxanthin, Lycopene and Retinol
  • Vitamin B6
  • Vitamin B9
  • Vitamin B12
  • Vitamin C
  • Vitamin D
  • Vitamin E
  • Vitamin K
  • Phosphorus (deficiency and overload)
  • Calcium
  • Zinc
  • Selenium
  • Magnesium
  • Iron
  • Coenzyme Q10

Response to inflammatory stimuli

The test is used to evaluate your genetic predisposition towards inflammation (acute and chronic), interrogating all the genes involved – at a cellular level – in a possible pro-inflammatory state. Chronic inflammation, on the other hand, is a condition of persistent irritation that may not cause symptoms for years but can be more destructive to vital tissues than acute inflammation. It involves immune balance glycation phenomena, damage from free radicals, and related oxidative stress. There are many pathologies associated with chronic inflammation, many of which are related to the aging process: cardiac, such as stroke, myocardial infarction, and atherosclerosis; allergic, including sinusitis, eczema, and asthma; autoimmune, such as lupus erythematosus, psoriasis, rheumatoid arthritis, and osteoporosis; neurological such as some types of Alzheimer’s. The applications of this module are many and can help you find the right strategy to live well and long.

Genetic areas analyzed

  • AACT, CRP, IFNG, IL1B, IL6, IL6R, IL10, TNFα, AGER, ATG16L1, CTLA4, TMEM25

Statistical algorithms (PRS – Polygenic Risk Score)

  • Risk of cellular inflammation
Related markers

C-reactive protein, interferon-gamma, IL1, Il6, IL10, TNF-alpha, arachidonic acid.

Drug metabolism

From a pharmacological point of view, it has been observed that the concentration level of a drug in the blood of patients who have taken the same dose can vary substantially (up to five times). Consequently, some patients risk being exposed to possible negative side effects caused by too high a concentration of the drug in the blood, despite taking the recommended dose; vice versa, in the blood of other patients the actual level could be too low, nullifying the effectiveness of the treatment. The Pharmacogenomics module can help to identify the genetic differences that underlie the variability of the different responses to drugs and to design highly effective personalized therapies. Drugs that are evaluated within the gene set are antidepressants, antipsychotics, antibiotics, protease inhibitors, beta-blockers, analgesics, antihypertensives, anticoagulants, hypoglycemics, and nonsteroidal anti-inflammatory drugs (NSAIDs).

Genetic areas analyzed

  • CYP1A2 (*1F, *1K, *8)
  • CYP2C9 (*2, *3, *4, *5, *6, *8, *11, *13)
  • CYP2C19 (*2, *2B, *3, *5, *6, *7, *8, *9, *10, *11, *17)
  • CYP2D6 (*3A, *6, *7, *8, *12, *20, *41)
  • CYP3A4 (*1B)
  • GNB3

CYP1A2

Antidepressants – Imipramine, amitriptyline, clozapine, diazepam, olazepine, carbamazepine.

CYP2C9

Anticoagulants – Acenocoumarol, phenprocoumon, warfarin.

Anti-inflammatories (NSAIDs) – Celecoxib, diclofenac, etodolac, ibuprofen, indomethacin, lornoxicam, mefenamic acid, suprofen, tenoxicam.

Antihypertensives – Irbesartan, losartan.

Oral hypoglycemics – Chlorpropamide, glibenclamide, gliclazide, glimepiride, nateglinide, tolbutamide.

Others – Bosentan, fluvastatin, mestranol, phenytoin, torsemide.

CYP2C19

Antidepressants – Imipramine, amitriptyline, clomipramine, citalopram and moclobemide, diazepam, desmethyldiazepam.

Anticonvulsants – Mephenytoin.

Antiulcer – Omeprazole.

CYP2D6

Analgesics – Acetoaminophen, hydroxycodone, methadone, oxycodone, tramadol, codeine.

Antidepressants – Amitriptyline, bupropion, clomipramine, desipramine, doxepin, fluoxetine, fluvoxamine, imipramine, nortriptyline, paroxetine, tradozone, trimipramine, venlafaxine.

Antipsychotics – Haloperidol, chlorpromazine, fluphenazine, mesoridazine, olanzapine, perphenazine, risperidone, thioridazine.

Cardiovascular – Alprenolol, carvedilol, flecainide, mexiletine, metoprolol, penbutol, propranolol, propafenone, timolol, verapamil.

Others – Amphetamines, atomoxetine, chlorpheniramine, cyclobenzodiazapines, dextromethorphan, doxorubicin, metochlorpramide, ondansetron, ranitidine, tamoxifen, thymol.

CYP3A4

Antidepressants – Imipramine, amitriptyline, sertraline, venlafaxine, nefazodone.

Macrolide antibiotics – Clarithromycin, erythromycin, troleandomycin.

Antifungal – Ketoconazole, astemizole.

Benzodiazepines – Alprazolam, triazolam, midazolam.

Calcium channel blockers – Diltiazem, felodipine, nimodipine, nifedipine, nisoldipine, nitrendipine, verapamil.

Immunosuppressives – Cyclosporine, tacrolimus.

HMG-CoA reductase inhibitors – Lovastatin, simvastatin, atorvastatin.

Protease inhibitors – Ritanovir, indinavir, nelfinavir, saquinavir.

Opioids – Alfentanil, fentanyl, sulfentanyl.

Steroids – Budesonide, cortisol, progesterone, 17-betaestradiol, testosterone.

Others – Carbamazepine, cisapride, dexamethasone, erythromycin, ethinyl estradiol, glyburide, theophylline, terfenadine.

GNB3

Antidepressants – Amitriptyline, bupropion, clomipramine, desipramine, doxepin, fluoxetine, fluvoxamine, imipramine, nortriptyline, olazepine, paroxetine, sertraline, tradozone, trimipramine, venlafaxine.

Others – Sumatriptan, sibutramine.

Frequently Asked Questions

Where can the sample be collected?

You can collect the sample in the comfort of your home.

Where will my sample be sent & who will do the analysis?

Using the DHL waybill provided with the test kit, you will be sending your sample back to our diagnostic laboratory where we will be performing the analysis.

How long before I receive my results?

After your sample is received by our lab, it will be analyzed and a result will be sent to you within 4 weeks.

Does the result need to be evaluated?

Should you require a consultation regarding this result, you may contact your medical doctor, otherwise, we can recommend you to our consultant immunologist.

Do you ship this test worldwide?

The test is currently only available for those living in the EU.

For UK customers, kindly send us an email to [email protected].