The BioArte’s advanced Gut Microbiota test kit

The kit includes; 2 collection tubes in each kit, including expert consultation + personalised diet recommendations and probiotic intake.

With the revolutionary Gut test kit from The BioArte, discover the mysteries of your gut flora like never before. Our state-of-the-art technology surpasses the competition by providing you with a thorough analysis that reaches the species level, which is based on our proprietary full-length 16s approach.

What distinguishes us is this:

Precision at the Species Level: The BioArte Gut test kit is intended to give you comprehensive information at the species level, in contrast to other gut microbiota examinations. To guarantee unmatched precision and specificity in identifying the microorganisms present in your gut, we sequence all nine variable regions (V1-V9), in contrast to others in the market who only sequence a limited percentage (mostly V3-V4).

Taxonomic Depth: We can explore the taxonomy of your gut microbiota in great detail thanks to our cutting-edge sequencing technology. You’ll be equipped with exact knowledge when you get a complete analysis of all the species that live in your digestive tract.

Thorough Analysis: The BioArte’s Gut test kit covers a lot of ground. Our comprehensive analysis of your gut microbiota delivers a holistic understanding of the microbial ecosystem within you.

Scientific Precision: We maintain the highest levels of scientific rigour at The BioArte. Our unique 16s method is supported by thorough research, guaranteeing the accuracy and dependability of our findings. To minimise variability, our gut kit asks for the collection of two samples as opposed to one.

Personalised Insights: Your general health and wellbeing are greatly influenced by the composition of your gut bacteria. You will obtain insights into your body’s immunity, digestion and other aspects of your health.

Simple to use Kit: Gathering a sample for examination is the easiest part of the process. Our easy-to-follow, step-by-step instructions make the process quick and easy. Two samples must be collected in order to allow for a comparison of the outcomes. We may perform insightful comparisons between these two samples by examining them to find trends and variances in the data. This comparison is essential for identifying any differences or patterns that could offer insightful information about the person’s gut health or other variables under evaluation, facilitating a thorough examination of the person’s health or condition.

Join the countless people who have already felt the difference after using our Gut microbiota analysis. With the information provided by our gut test kit, you will be prepared to make wise choices regarding your wellbeing. Place your order for your kit right now to start on the path to better health.

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Sample: Stool
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Price: various depending on additional tests & services added to the test

For clients in Malta: this test can be paid & collected from any Brown’s pharmacy.

  • Advanced Gut Microbiota test kit

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Timing for test results: 3 Weeks after the samples have been delivered to our diagnostic lab.
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Evaluation of results: Recommendations & private consultation with our microbial expert OR evaluation via your own medical doctor.

Information that is found in the final report

Why we check only the 5 main Bacterial phyla

The amount of bacterial cells in the gut has been estimated at 1011 to 1013 per gram which makes the intestinal tract one of the most densely populated microbial habitats on earth. The gut microbiome encodes over 3 million genes producing thousands and thousands of metabolites.

The dominant gut microbial phyla are Firmicutes, Bacteroidetes, Actinobacteria, Proteobacteria, Cyanobacteria, Fusobacteria, and Verrucomicrobia, with the two phyla Firmicutes and Bacteroidetes representing 90% of gut microbiota, followed by Actinobacteria and Cyanobacteria. They are represented differently depending on the basis of age and geography.

In particular, Firmicutes, Bacteroidetes, Actinobacteria, Proteobacteria, and Cyanobacteria represent the cornerstones of the intestinal ecosystem being involved in the 3 main physiological duties:

  1. Trophic
  2. Metabolic
  3. Immunological

A disbalance, or dysbiosis, of these phyla, can cause gut microbiota physiological variations followed by huge implications in intestinal and extra-intestinal disorders. This dysbiosis is often defined as an alteration of gut microbiota composition and a cause or a consequence of disorders. A chronic change of these fine and interconnected phyla abundances by external stimulation may be stressful and disruptive for this ecosystem.

Why we provide the ratio of Firmicutes and Bacteroidetes

Firmicutes and Bacteroidetes are the two major and dominant bacterial phyla in human gut microbiota. The Firmicutes to Bacteroidetes ratio (F/B ratio, conventionally around 1) has been extensively examined in the past in human and mouse gut microbiota as a marker of weight gain or loss, but recent discoveries have associated F/B ratio to many metabolic disorders and chronic diseases. This ratio is influenced by diet and age. The Firmicutes/Bacteroidetes ratio undergoes an increase from birth to adulthood and is further altered with advanced age. This ratio appears applicable in highlighting variations between infants, adults, and the elderly. It can be linked to overall changes in bacterial profiles at different stages of life.

F/B ratio can also be used to evaluate the metabolic absorption of the intestine, which can influence the intake of calories or a predisposition to lose or gain more calories, when the ratio is below or above 1, respectively. Of course, these measurements should be done longitudinally, and in particular useful to follow the trend of the gut microbiota during a slimming diet or the use of foods rich in sugar.

Why we analyse the Biodiversity

Microbial diversity (or Biodiversity) describes the number of different species of microbes present and their distribution in the gut. A reduction in diversity causes a microbial imbalance or dysbiosis. Gut microbial diversity generally decreases when people age, which is likely due to changes in physiology, diet, medication, and lifestyles. Decreased diversity is considered to be an indicator of an unhealthy microbiome, and it has been linked to different chronic conditions. Reduced microbial diversity has been in fact observed in various chronic health conditions, including inflammatory bowel disease and Crohn’s disease, type 1 and 2 diabetes, psoriatic arthritis, cardiovascular disease, obesity, allergies, and many immunological disorders.

The determination of microbial diversity involves sequencing data from 16S rRNA genes amplified from gut microbial samples which, with the use of computational analysis and dedicated software platforms, allows to determine the microbial diversity richness and the distance between bacterial clusters (Alpha or Beta-diversity analysis or other metrics are generally used).

Why we check for Pro and Anti-inflammatory strains

The gut microbiota plays a huge role in maintaining overall health (it is even connected to other organs such as; the brain, skin, oral, vaginal, respiratory tract, etc), particularly as it relates to inflammatory disease. According to the recent literature, the gut microbiome influences the balance of pro-and anti-inflammatory responses in our digestive system and throughout our immune system. In particular, the specific microbial clusters can influence the gut and other organs’ inflammatory responses.

We know now that there is an association between the gut microbiome in the promotion of inflammation. This can be triggered from animal-based food, processed food, grain-based foods, alcohol, and sugar can promote some diseases:

  • heart disease
  • inflammatory bowel diseases
  • systemic lupus erythematosus
  • rheumatoid arthritis
  • diabetes
  • gut, skin, and brain disturbances

That’s why it is important to know the bacteria that are able to protect from or promote inflammation, respectively. Recognize and identify “opportunistic” microbes that, after the intake of certain foods, can be also very relevant to avoid or decrease the inflammation processes.

Examples of bacteria that have links with inflammation are; Clostridium, Prevotella, Alistipes, etc. whose growth is also facilitated in individuals that consume a cluster of meats, french fries, mayonnaise, and soft drinks.

Examples of “friendly” bacteria having anti-inflammatory properties are; Bifidobacterium, Lactobacillus, Akkermansia, etc. Their presence in the gut is related to a qualified Mediterranean diet.

When an imbalance occurs, it may influence a diverse range of inflammatory-mediated conditions.

Only scientific and international approved literature is considered for Microbiota testing with The BioArte

Many tests actually proposed by labs, pharmacies, etc, may not have a sufficient degree of scientific validity and therefore should be avoided. The only tests with a minimum of reliability are those that genetically analyze the microbiota (genomic map) by using skills, DNA sequencing tools, and bioinformatic interpretation of high proficiency. The interpretation of the Microbiota genetic map needs to be performed by a Clinical Microbiota Expert, which is of fundamental importance.

Prof. Lorenzo Drago, a Microbiota Expert, reports “Metagenomic analysis of microbiota is a big and complex screenshot of thousands of microbial genetic information. Before carrying out a test for the Microbiota, it must be realized that investigating in advance the healthy status of subjects or patients is mandatory. This is where it must start if we want to understand the correlation between the state of the microbiota in those subjects who suffering from any disturbance and the alterations of the intestinal bacterial flora. Many stages of research are at the beginning, but we can do a lot about the possibility of treating or preventing certain diseases through the manipulation of the microbiota. Using the right food, diet, prebiotics, and/or probiotics is not child’s play, but it requires high competence and specialization in the field. We should try do not to give false interpretations and expectations to the patient, but only aim towards presenting correct suggestions based on true scientific concepts and internationally accepted literature.”

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